Best or Most effecient way to update data remotely

Hello,

I am developing a software in which I need to update local data entered in my software to a remote MySQL database (when a PC is connected to internet).

The amount of data generation is quite huge so I would like to know the best and most band width efficient way to send data to remote MySQL database as well as get back from MySQL database to my local database.

Can some one please suggest so good strategy to follow.

I have got 21 tables and average fields are 63 per table. Each table has more than 40,000 records and adding on daily basis.

To access MySQL I am using the free ActiveX MyVBQL.dll.

Thanks in advance.

Regards,

Yogi Yang